Roth Lab - Positions

Available Lab Positions

We are always looking for highly motivated individuals to join the lab. Please email the appropriate contact for more information.




Several Post-Doctoral
Dr. Roth's laboratory has interests in G-Protein Coupled Receptors, Signal Transduction and Drug Discovery. The lab is the main site for the NIMH Psychoactive Drug Screening Program and has many on-going collaborations. Highly experienced as well as newly graduated PhD's are encouraged to apply. Expertise in the pharmacology, cell signaling and/or biochemistry of GPCR's is desired. Knowledge of molecular biology and biochemistry, commensurate with experience, is required. Representative publications: Salvinorin A: A potent naturally occurring nonnitrogenous kappa opioid selective agonist. Roth BL et al. Proc Natl Acad Sci U S A. 99(18): 11934-11939, 2002 The human polyomavirus, JCV, uses serotonin receptors to infect cells. Elphick et al Science. 306(5700):1380-3, 2004 p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling Sheffler et al Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0600585103. Finding new tricks for old drugs: an efficient route for public-sector drug discovery. O'Connor KA, Roth BL. Nat Rev Drug Discov. 2005 Dec;4(12):1005-14.
Graduate Student
PDSP Research Technician
The laboratory of Dr. Bryan Roth in UNC Dept of Pharmacology is seeking a motivated graduate in a scientific field (biology, chemistry, biochemistry, etc.) as a PDSP Research Technician. The PDSP Receptor Binding Technician performs routine assays on a daily basis. Three major work responsibilities:
  1. Perform experiments (binding assays, functional assays, etc.) according to established protocols. Ensure availability of all reagents and supplies for future experiments.
  2. Maintain data and experimental notes in an organized fashion with complete integrity. Under direction from supervisors utilize the PDPS Database to record and submit assay results and ensure proper assay performance.
  3. General lab tasks: communicate need for chemicals, supplies and lab materials, perform routine laboratory maintenance and cleaning.
Essential Skills, Knowledge and Abilities:
Basic knowledge to perform duties and use scientific instruments. Conduct routine tests consistently with accuracy and precision. Maintain highly organized data and experimental records. Ability to manage multiple tasks simultaneously. Experience with pipetting required. Familiarity with PC’s, MS office programs, e-mail clients and browsers.

Preferred Qualifications:
Bachelor's degree in a scientific field (biology, chemistry, biochemistry, etc.) from an accredited university. One year of laboratory experience in a biological field is preferred. A fine attention to detail is required for this work. Ability to follow published protocols. Fine acuity to measure small quantities of rare, expensive or fine chemicals. Long periods of standing may be involved. Required to work with radioactive materials. Must be able communicate effectively with supervisors

This is a temporary, full time position that could become permanent.
Send resumes: Estela Lopez
ADA/EOE employer.