Roth Lab in the news:
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Recent:
- devices_otherResearchers Wrestle with Accuracy of AI Technology Used to Create New Drug Candidates
- devices_otherAI Program Finds Thousands of Possible Psychedelics. Will They Lead to New Drugs?
- devices_otherResearchers Using AI To Develop New Psychedelics
- devices_otherInternational ranking includes 41 “highly cited researchers” at Carolina
- devices_otherNorth Carolina lawmakers look to fund research on psychedelic drugs
- devices_otherPsychedelics for Therapy: What to Know About Benefits and Risks
- devices_otherScientists Take Another Step Toward Creating Better Pain Medications
- devices_otherVirtual library of LSD-like drugs could reveal new antidepressants
- devices_otherA drug based on LSD appears to treat depression in mice without the psychedelic trip
- devices_otherLSD-Like Molecules Counter Depression Without the Trip
- devices_otherTaking the Magic Out of Magic Mushrooms
- devices_otherRoth Leads $26.9 Million Project to Create Better Psychiatric Medications
- devices_otherHow psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more
- devices_otherAnecdotal Evidence and the Need for Trials of Psychedelics in Headache Disorders: Bryan Roth, MD, PhD
- devices_otherAssessing Psychedelics for Therapeutic Potential in Cluster Headache: Bryan Roth, MD, PhD
- devices_otherUNC doctor studying how psychedelics can treat some mental illnesses
- devices_otherExplaining what causes different psychedelic experiences is a trip. This study shows why.
- devices_otherUNC professor shares personal motivation for studying psychedelics as possible treatment for mental illness
- devices_otherDrug companies are investing big in psychedelics, but can they engineer out the trip?
- devices_otherScratching the itch with cryo-EM
- devices_otherGrowing interest in psychedelic therapy reveals two different visions of the future: one of spiritual interconnectedness and one of sober neurochemistry.
- devices_otherScientists Unveil Drug Discovery Tool to Screen More Than 11 Billion Compounds
- devices_otherResearchers Reveal Structure of Itch Receptors on Cells
- devices_otherWhy a UNC professor is on a quest to remove the ‘trip’ from psychedelic drugs
- devices_otherThe Future Of Psychedelic Medicine Might Skip The Trip
- devices_otherScientists are Using AI to Develop New Psychedelic Drugs
- devices_other‘Pharmacopeia’ Season Finale Features Cutting Edge Psychedelic Research
- devices_otherWhat Removing the “Hallucinations” from Psychedelics Means for Psychotherapy
- devices_otherA Scientific First: How Psychedelics Bind to Key Brain Cell Receptor
- devices_otherScientists Solve High-Resolution Structure of Psychedelic Drugs Bound to Serotonin Receptors
- devices_otherA scientific first: How psychedelics bind to key brain cell receptor
- devices_otherResearchers develop a selective chemogenetic actuator to rapidly control neuronal activity and behavior
- devices_otherCongrats to Justin English who is now an Assistant Professor of Biochemistry at the University of Utah Medical School.
- devices_otherRoth Leads $26.9 Million Project to Create Better Psychiatric Medications
- devices_otherScientists Reveal Host- SARS-CoV-2 Protein Targets for Drug Repurposing
- devices_otherA New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors
- devices_other'Virtual Pharmacology' Yields Unprecedented Biological Clock Breakthrough
- devices_otherNovel melatonin receptor molecules potentially address circadian rhythm disturbances
- devices_otherDr. Bryan L. Roth Named Highly Cited Researcher
- devices_otherUNC Lineberger faculty honored for highly cited research
- devices_otherScientists Invent Fast Method for ‘Directed Evolution’ of Molecules
- devices_otherThe Scientist’s Drug Dealer: How Researchers Get Illicit Drugs
- video_libraryBryan Roth: Understanding Drugs, Understanding the Brain
- devices_otherA good night's sleep may be in sight
- verified_userDr. Bryan L. Roth elected to American Academy of Arts and Sciences
- devices_otherPrefer Menthol to Regular Cigarettes? It May Be Your Genetics
- event_noteMassive chemical libraries, and CRISPR-CasX
- verified_userMega Docking Library Poised to Speed Drug Discovery
- event_noteUltra-large virtual molecular libraries throw open chemical space
- event_noteSOM Researchers Make International Highly Cited Research List
- devices_other(Download) This is Your Brain on DREADDs
- devices_otherThis is Your Brain on DREADDs
- devices_otherScientists Discover Intricacies of Serotonin Receptor Crucial for Better Therapeutics
- devices_otherScientists discover intricacies of serotonin receptor crucial for better therapeutics [Report]
- devices_otherUNC researcher works to help people who may become addicted to opioid medicines
- devices_otherThe opioid crisis (Interview with Dr Bryan Roth)
- event_noteOpioids dont have to be addictive the new versions will treat pain without triggering pleasure
- verified_userRoth, Johnson awarded $28 million for Illuminating Druggable Genome NIH grants
- event_notePain relief: designing better opioids
- verified_userFrom Salvia Divinorum to LSDToward a Molecular Understanding of Psychoactive Drug Actions
- verified_userMolecular Picture Points the Way to Better Antipsychotic Medications
- event_noteA new era of rationally designed antipsychotics
- event_noteStructure of antipsychotic drug target solved
- event_noteSCIENTISTS JUST SOLVED A MAJOR PIECE OF THE OPIOID PUZZLE
- event_noteScientists create a 'better' opioid that relieves pain without being addictive - a breakthrough that could put an end to the deadly crisis sweeping America
- event_noteNew Painkiller Discovery Could Lead to First Non-Addictive Opioid Drug
- event_noteBreakthrough brings non-addictive opioid alternatives a step closer
- event_noteScientists Take a Big Step toward Building a Better Opioid
- devices_otherInterviews with Scientists: Dr Bryan Roth
- event_noteGPCRs: Crystal structure of D4 dopamine receptor
- event_noteNew painkillers could thwart opioids’ fatal flaw
- event_noteA Key Psychiatric Drug Target Comes Into Focus
- event_noteA new pocket for D4 - Crystal structure paves way to dopamine D4 receptor-selective agonists
- verified_userStructure guides design of dopamine receptor binding compound
- event_noteTeam determines first high-resolution structure of dopamine receptor
- event_noteBiased for benefit: Stimulating the world's most popular drug targets with more nuance
- verified_userRodbell Lecture — G-proteins, DREADDs, and drug discovery
- verified_userUNC researchers link orphan receptor to opioid-induced itching
- event_noteLSD-Bound Serotonin Receptor Crystallized
- verified_userPromising Advances in the Search for Safer Opioids
- event_noteCrystal Structure of an LSD-Bound Human Serotonin Receptor
- event_noteFirst look at LSD in action reveals acid-trip biochemistry
- event_note2016: Signaling Breakthroughs of the Year
- verified_userExperimental therapy for Prader-Willi syndrome shows promise in mice
- event_noteNew and Old Techniques in Modern Neuroscience
- verified_userDesigner Agent Blocks Pain in Mice Without Morphine’s Side Effects
- verified_userResearchers build a better opioid painkiller from scratch
- devices_otherW-18 Is Not A Super-Potent Designer Opioid As Originally Believed
- verified_userUNC SOM faculty recognized by Reuters as Highly Cited Researchers
- devices_otherCanada Says One Test on Mice From the '80s Proves That W-18 Is 100 Times Stronger Than Fentanyl
- verified_userDuke-UNC Collaboration May Lead to Drug Discovery Boom
- verified_userBryan Roth, of Salvanorin A and DREADD fame, was honored by ASPET with the Goodman and Gilman award at EB
- verified_userWe made the cover of TiPS
- verified_userReid Olsen Winner of 2015 Joy Cappel Young Investigator Award
- verified_userReid Olsen Honored with Tanner Teaching Assistants Award for Excellence in Undergraduate Teaching
- verified_userNeuron Best of 2014/15
- verified_userLouis S. Goodman & Alfred Gilman Award in Receptor Pharmacology
- event_noteIlluminating orphan GPCRs
- verified_userDr. Roth gives THE THEODORE KOPPANYI LECTURESHIP IN PHARMACOLOGY
- verified_userNovel Technique Uncovers "Dark" G-Protein Coupled Receptors: Implications for Drug Discovery
- devices_otherResearchers shed pharmacological light on formerly 'dark' cellular receptors
- verified_userResearchers shed pharmacological light on “dark” cellular receptors
- verified_user2015 Goodman Lecture Speaker, Bryan Roth, Ph.D. - "Illuminating a subterranean pharmacology"
- event_noteRemote Mind Control
- verified_userNeural circuitry of brain regions involved in decision-making
- event_noteMessage From President Steve Hyman: The Promise of BRAIN
- verified_userNIH BRAIN initiative Multi-Council Working Group Meeting
- event_noteUn año dentro del cerebro
- event_noteChemogenetic manipulation of neurons
- verified_userEarly BRAIN Breakthroughs
- verified_userControlling Brain Circuits in Mice
- verified_userA BRAIN Initiative first: new tool can switch behavior ‘on’ and ‘off’
- verified_userObama's BRAIN Initiative yields first study results
- event_notePRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
- verified_userStrategic Objective 1: Define the Mechanisms of Complex Behaviors
- verified_userHomes for Receptors
- event_note2014: Signaling Breakthroughs of the Year
- verified_userRoth’s novel research technique, DREADDs, lands him on Top 10 List
- video_libraryKetamine: A Quick Guide to Receptors
- verified_userInstitute of Medicine Elects 70 New Members, 10 Foreign Associates
- verified_userBryan Roth Awarded - Dreadd 2.0: An Enhanced Chemogenetic Toolkit
- video_libraryDREADD toolkit is nicely highlighted around 3hr 20min
- event_noteMassive schizophrenia genomics study offers new drug directions
- video_libraryNovel psychoactive substances - understanding the pharmacological basis of their clinical effects and toxicity
- verified_userNIH launches new program to find potential drug targets
- event_noteBryan Roth has been named Deputy Editor for the Journal of Clinical Investigation
- event_noteGPCR Insights Brighten Drug Discovery Outlook
- devices_otherScientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
- devices_otherUnlocking sodium's role in brain boost for new drugs
- verified_userBesnard et al, Automated design of ligands to polypharmacological profiles
Besnard et al, Automated design of ligands to polypharmacological profiles
Study Paves Way to Design Drugs Aimed at Multiple Protein Targets at Once
Drug Design On The Fast Track
NARSAD Grantee Leads Work in Designing More Effective Medications
Computational chemistry: Homing in on desired drug properties
- event_noteDrug Discovery: Structure-led design
- devices_otherWhere Are All the Miracle Drugs?
- verified_userUnlocking the Secrets of Our Cells: The Nobel Prize
- verified_userWacker et al, Structural Features for Functional Selectivity at Serotonin Receptors
Wacker et al, Structural Features for Functional Selectivity at Serotonin Receptors
New Technology Enables New Insights Pointing toward Safer Schizophrenia Medications
Avoiding The Death Receptor
Study reveals how serotonin receptors can shape drug effects from LSD to migraine medication
Serotonin receptors offer clues to new antidepressants
The Structure of Bias at Serotonin Receptors
Experimenting With LSD, Scientists Decipher Two Serotonin Receptors
- verified_userAlzheimer research Forum: In the spotlight New Orleans Draws Neuroscientists, Seriously
- event_noteGarner et al, Generation of a Synthetic Memory Trace
- verified_userWu et al, Structure of the human kappa-opioid receptor in complex with JDTic
- verified_userHuang et al, Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
- verified_userAllen et al, Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
- verified_userDrug-induced valvular heart disease and serotonin receptors
- event_note2009 Keiser paper
- event_noteDrug discovery: Predicting promiscuity
- event_noteNew targets for old drugs
- devices_otherSolving a 40-year-old mystery, UNC researchers find new route for better brain disorder treatments
- event_noteDrug discovery: Playing dirty
- verified_userk opioid receptors, Salvia divinorum and hallucinogen salvinorin A
k opioid receptors, Salvia divinorum and hallucinogen salvinorin A
Salvia ingredient studied as medical treatment
Why scientists think salvia could lead to medical treatments
Salvia: legal herb hallucinogen draws teens, critics
Popularity of a hallucinogen may thwart its medical
Salvia: A Virtual Drug Craze
CBS News Early Show
- event_noteRothlab publications highlighted by Faculty of 1000
